|
|
aklavinone + NADPH + H+ + O2 <=> epsilon-rhodomycinone + NADP+ + H2O
|
1.14.13.180
aklavinone 12-hydroxylase
|
–
|
| |
BRENDA:
BR50586
KEGG:
R06683
MetaCyc:
RXN-14824
|
|
|
|
6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate <=> 12-deoxyaklanoate + H2O
|
4.2.1
|
–
|
| |
MetaCyc:
RXN-17998
|
|
|
|
S-adenosyl-L-methionine + aklanonate <=> S-adenosyl-L-homocysteine + methyl_aklanonate
|
2.1.1.288
aklanonic acid methyltransferase
|
–
|
| |
BRENDA:
BR50636
KEGG:
R06680
MetaCyc:
RXN-14831
|
|
|
|
13-dihydrocarminomycin + NADPH + H+ + O2 <=> carminomycin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
| |
BRENDA:
BS421771
KEGG:
R06692
MetaCyc:
RXN-16479
|
|
|
|
S-adenosyl-L-methionine + carminomycin <=> daunorubicin + S-adenosyl-L-homocysteine + H+
|
2.1.1.292
carminomycin 4-O-methyltransferase
|
–
|
| |
BRENDA:
BR50635
KEGG:
R06693
MetaCyc:
RXN-14828
|
|
|
|
S-adenosyl-L-methionine + 13-dihydrocarminomycin <=> 13-dihydrodaunorubicin + S-adenosyl-L-homocysteine + H+
|
2.1.1.292
carminomycin 4-O-methyltransferase
|
–
|
| |
BRENDA:
BS422040
MetaCyc:
RXN-14833
|
|
|
|
10-carboxy-13-deoxycarminomycin + H+ <=> 13-deoxycarminomycin + CO2
|
4.1.1
|
–
|
| |
KEGG:
R06686
MetaCyc:
RXN-14827
|
|
|
|
13-deoxydaunorubicin + NADPH + H+ + O2 <=> 13-dihydrodaunorubicin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
| |
BRENDA:
BR50584
KEGG:
R06688
MetaCyc:
RXN-14829
|
|
|
|
S-adenosyl-L-methionine + 13-deoxycarminomycin <=> 13-deoxydaunorubicin + S-adenosyl-L-homocysteine + H+
|
2.1.1.292
carminomycin 4-O-methyltransferase
|
–
|
| |
BRENDA:
BS424026
KEGG:
R06687
MetaCyc:
RXN-14826
|
|
|
|
epsilon-rhodomycinone + dTDP-L-daunosamine <=> rhodomycin_D + dTDP + H+
|
2.4.1
|
–
|
| |
KEGG:
R06684
MetaCyc:
RXN-14825
|
|
|
|
13-deoxycarminomycin + NADPH + H+ + O2 <=> 13-dihydrocarminomycin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
| |
BRENDA:
BS421769
KEGG:
R06691
MetaCyc:
RXN-16478
|
|
|
|
9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] <=> 6-[3-hydroxy-2-(3,5,7-trioxononanoyl)phenyl]-3,5-dioxohexanoate + polyketide-[acp] + H2O + H+
|
4.2.1
|
–
|
| |
MetaCyc:
RXN-14874
|
|
|
|
rhodomycin_D + H2O <=> 10-carboxy-13-deoxycarminomycin + methanol + H+
|
3.1.1
|
–
|
| |
KEGG:
R06685
MetaCyc:
RXN-14856
|
|
|
|
aklavinone + NADP+ <=> aklaviketone + NADPH + H+
|
1.1.1.362
aklaviketone reductase
|
–
|
| |
BRENDA:
BR50595
KEGG:
R06682
MetaCyc:
RXN-14818
|
|
|
|
12-deoxyaklanoate + O2 <=> aklanonate + H2O
|
1.13.12
|
–
|
| |
KEGG:
R06679
MetaCyc:
RXN-14854
|
|
|
|
propionyl-CoA + malonyl-CoA + polyketide-[acp] + H+ <=> 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + CO2 + CoA
|
2.3.1
|
–
|
| |
MetaCyc:
RXN-14846
|
|
|
|
aklaviketone <=> methyl_aklanonate
|
5.5.1.23
aklanonic acid methyl ester cyclase
|
–
|
| |
BRENDA:
BR50726
KEGG:
R06681
MetaCyc:
RXN-14844
|
|
|
|
9-hydroxy-3,5,7,11,13,15,17,19-octaoxohenicosanoyl-[acp] + NADP+ <=> 3,5,7,9,11,13,15,17,19-nonaoxohenicosanoyl-[acp] + NADPH + H+
|
1.1.1
|
–
|
| |
MetaCyc:
RXN-14875
|
|
|
|
13-dihydrodaunorubicin + NADPH + H+ + O2 <=> daunorubicin + NADP+ + H2O
|
1.14.13.181
13-deoxydaunorubicin hydroxylase
|
–
|
| |
BRENDA:
BR50585
KEGG:
R06689
MetaCyc:
RXN-14830
|
|
